PLMD Protein Information


Tag Content
PLMD ID PLMD-0001233
Uniprot Accession O43715; B2R4Z7; Q5RKS5; Q6LCA7
Genbank Protein ID AF161481; AL021546; AK312006; CH471054; BC002638; BC055313; U75688
Genbank Nucleotide ID AAF29096.1; CAA16495.1; BAG34944.1; EAW98192.1; AAH02638.1; AAH55313.1; AAR00584.1
Protein Name TP53-regulated inhibitor of apoptosis 1
Protein Synonyms/Alias Protein 15E1.1
WF-1
p53-inducible cell-survival factor
p53CSV
Gene Name TRIAP1
HSPC132
Gene Synonyms/Alias 15E1.1
Organism Homo sapiens
NCBI Taxa ID 9606
Functional Description
(View all)
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).
Lysine Modification
PLMD PTMs: 5
PositionPeptidesTypeReferences ( PMIDs )
12GEACTDMKEYDQCFAcetylation27452117
26FNRWFAEKLKGDSSUbiquitination21890473; 23603789
42DPCTDLFKYQQCVQAcetylation26822725; 27452117
50RYQQCVQKIKEKEIAcetylation26051181
55VQKAIKEKIPIEGLAcetylation25953088
Sequence
(Fasta)
MNSVGEACTD MKREYDQCFN RWFAEKFLKG DSSGDPCTDL FKRYQQCVQK AIKEKEIPIE 60
GLEFMGHGKE KPENSS 76
Sequence Annotation CHAIN 1 76 TP53-regulated inhibitor of apoptosis 1.
DOMAIN 5 55 CHCH. {ECO:0000255|PROSITE-
COILED 1 52 {ECO:0000269|PubMed:26071602}.
MOTIF 8 18 Cx9C motif 1. {ECO:0000255|PROSITE-
MOTIF 37 47 Cx9C motif 2. {ECO:0000255|PROSITE-
SITE 27 27 Important for interaction with PRELID3A.
SITE 41 41 Important for interaction with PRELID3A.
MOD_RES 1 1 N-acetylmethionine.
DISULFID 8 47 {ECO:0000244|PDB:4XZS,
DISULFID 18 37 {ECO:0000244|PDB:4XZS,
MUTAGEN 27 27 F->A: Impairs interaction with PRELID3A.
HELIX 2 25 {ECO:0000244|PDB:4XZS}.
HELIX 27 29 {ECO:0000244|PDB:4XZS}.
HELIX 38 51 {ECO:0000244|PDB:4XZS}.
Keyword

KW-0002--3D-structure.
KW-0007--Acetylation.
KW-0053--Apoptosis.
KW-0175--Coiled coil.
KW-0181--Complete proteome.
KW-0963--Cytoplasm.
KW-1015--Disulfide bond.
KW-0445--Lipid transport.
KW-0496--Mitochondrion.
KW-1185--Reference proteome.
KW-0813--Transport.

Interpro

IPR007918--MDM35_apoptosis.

PROSITE

PS51808--CHCH.

Pfam

PF05254--UPF0203.

Gene Ontology

GO:0005758--C:mitochondrial intermembrane space.
GO:0005739--C:mitochondrion.
GO:0048471--C:perinuclear region of cytoplasm.
GO:0043234--C:protein complex.
GO:0002039--F:p53 binding.
GO:0006915--P:apoptotic process.
GO:0034644--P:cellular response to UV.
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator.
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest.
GO:0043066--P:negative regulation of apoptotic process.
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process.
GO:1902166--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria.
GO:0015914--P:phospholipid transport.
GO:2001140--P:positive regulation of phospholipid transport.
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter.
GO:0042981--P:regulation of apoptotic process.
GO:0097035--P:regulation of membrane lipid distribution.

KEGG Pathway hsa:51499